This presentation will focus on the newly developed Topology Optimization technology now being used in Autodesk Nastran In-CAD software and also found in Autodesk Nastran standalone, Fusion 360 Ultimate software, Inventor Simulation software, and Dreamcatcher software. We will begin with an introduction of how Topology Optimization works, and then we'll focus on the Autodesk Nastran In-CAD interface for Topology Optimization. We will perform several examples that will include how to produce designs with minimized mass and maximized stiffness that comply with various design and manufacturing constraints. Examples will include minimized mass with stress and compliance design constraints and various manufacturing constraints such as additive and subtractive with symmetry. We will show a complete workflow that includes importing optimized .STL geometry and building a verification analysis model.